. 3


Selected Publications


62. Sherba, J.J., S. Hogquist, H. Lin, J.W. Shan, D.I. Shreiber, and Jeffrey D. Zahn. 2020. The effects of electroporation buffer composition on cell viability and electro-transfection efficiency. Nature Scientific Reports (accepted)


61. Fantuzzo, J.A., R.P. Hart, J.D. Zahn, and Z.P. Pang.  2019. Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. Developmental Dynamics.  248(1):65-77.

60. Zahn, J.D.  2019. Invited Editorial: Microdevice Development and Artificial Organs. Artificial Organs.  43(1):17-20.


59. Omelchenko, A., A.B. Shrirao, A.K.Bhattiprolu, J.D. Zahn, R.S.Schloss, S. Dickson, D.F. Meaney, N.N. Boustany, M.L.Yarmush and B.L. Firestein.  2019. Dynamin and reverse-mode sodium calcium exchanger blockade confers neuroprotection from diffuse axonal injury. Cell Death and Disease.  10:727.

58. Yu, M., A. Mahtabfar, P. Beelen, Y. Demiryurek, D. Shreiber, J. Zahn, R. Foty, L. Liu, and H. Lin.  2018. Coherent timescales and mechanical structure of multi-cellular aggregates. Biophysical Journal.  114(11):2703-2716.

57. Shrirao, A.B., Z. Fritz, S.C. Van Nostrand, E.M. Novik R.S. Schloss, J.D. Zahn, and M.L. Yarmush.  2018. Microfluidic Flow Cytometry: The role of microfabrication methodologies, performance and functional specification Technology.  6(1):1-23

56. Lo, M.C., S. Wang, S. Singh, V.B. Damodaran, I. Ahmed, K. Coffey, D. Barker, K. Saste, K. Kals, H.M. Kaplan, J. Kohn, D.I. Shreiber, and J.D. Zahn.  2018. Evaluating the In Vivo Glial Response to Miniaturized Parylene Cortical Probes Coated with an Ultra-Fast Degrading Polymer to Aid Insertion.  J. Neuroengineering  15(3): 036002.

55. Yu, M., A. Mahtabfar, P. Beelen, Y. Demiryurek, D.I.Shreiber, J.D. Zahn, R.A. Foty, L. Liu, and H. Lin.  2018. Coherent Timescales and Mechanical Structure of Multicellular Aggregates.  Biophysical Journal   114(11):2703-2716.

54. Shrirao AB, Fritz Z, Van Nostrand SC, Novik EM, Schloss RS, Zahn JD, and Yarmush ML.  "Microfluidic Flow Cytometry: The role of microfabrication methodologies, performance and functional specification."   Technology.  2018; 10(1142).

53. Lo, MC., Wang S, Singh S, Damodaran VB, Ahmed I, Coffey K, Barker D, Saste K, Kals K, Kaplan HM, Kohn J, Shreiber DI, and Zahn JD.  "Evaluating the In Vivo Glial Response to Miniaturized Parylene Cortical Probes Coated with an Ultra-Fast Degrading Polymer to Aid Insertion."  J. Neuroengineering .   15(3).


52. Fantuzzo, J.A., V.R. Mirabella, A. Hamod, R.P. Hart, J.D. Zahn, and Z.P. Pang.  2017. Intellicount: High-throughput quantification of synaptic protein puncta by machine learning. eNeuro.  4(6):e0219-17.

51. Fantuzzo, J.A., L. De Filippis, H. McGowan, N. Yang, Y.H. Ng, A. Halikere, J.J. Liu, R.P. Hart, M. Wernig, J.D. Zahn, and Z.P. Pang.12. Fantuzzo, J.A., L. De Filippis, H. McGowan, N. Yang, Y.H. Ng, A. Halikere, J.J. Liu, R.P. Hart, M. Wernig, J.D. Zahn, and Z.P. Pang.  2017. mNeurocircuitry: establishing in vitro models of neurocircuits with human neurons. Technology .  5(2):1-11 2017.

50. Zheng, M., J.J. Sherba, J.W. Shan, H. Lin, D.I. Shreiber, and J.D. Zahn..  2017. Continuous-flow, electrically-triggered, single cell-level electroporation. Technology..  5(1):1-11. *Featured on the AAAS EurekAlert website.

49. Shannon S, D. Jia, I. Entersz, P. Beelen, M. Yu, C. Carcione, J. Carcione, A. Mahtabfar, C. Vaca, M. Weaver, D. Shreiber, J.D. Zahn, L. Liu, H. Lin, and R.A. Foty.  2017. Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901.   BMC Cancer.  17(1):121.

48. Shrirao, A, Kung F, Omelchenko A, Schloss R, Boustany N, Zahn JD, Yarmush ML, Firestein B.  "Microfluidic platforms for the study of neuronal injury in vitro."   Biotechnology and Bioengineering.  2017; 115(4): 815-830.

47. Fantuzzo, JA, Mirabella VR, Hamod A, Hart RP, Zahn JD, Pang ZP.  "Intellicount: High-throughput quantification of synaptic protein puncta by machine learning."  eNeuro.   2017; 4(6).

46. Fantuzzo, J.A.,De Filippis L, McGowan H, Yang N, Ng YH, Halikere A, Liu JJ, Hart RP, Wernig M, Zahn JD, Pang ZP.   "Neurocircuitry: establishing in vitro models of neurocircuits with human neurons."  Technology.   2017; 5(2): 1-11.

45. Zheng, M., Sherba, JJ, Shan HW, Lin H, Shreiber DI, Zahn JD.  "Continuous-flow, electrically-triggered, single cell-level electroporation  Technology.  2017; 5(1): 1-11.

44. Shannon S, Jia D, Entersz I, Beelen P, Yu M, Carcione C, Carcione J, Mahtabfar A, Vaca C, Weaver M, Shreiber D, Zahn JD, Liu L, Lin H, Foty RA.  "Inhibition of glioblastoma dispersal by the MEK inhibitor PD03259010."  BMC Cancer.  2017; 17(121).


43. Singh S, Lo MC, Damodaran VB, Kaplan HM, Kohn J, Zahn JD, Shreiber DI.   "Modeling the insertion mechanics of coated flexible neural probes for optimizing probe design"  Sensors.   2016; 16(3): 330.

42. Zheng M, Shan JW, Lin H, Shreiber DI, Zahn JD.  "Hydrodynamically-controlled Cell Rotation in an Electroporation Microchip to Circumferentially Deliver Molecules into Single Cells."  Microfluidics and Nanofluidics.  2016; 20(16).


41. Ghodbane M, Stucky EC, Maguire TJ, Schloss RS, Shreiber DI, Zahn JD, Yarmush ML.   "Development and Validation of a Microfluidic Immunoassay Capable of Multiplexing Parallel Samples Using Commercially Available Reagents."  Lab on a Chip.  2015; 15(15): 3211-21.

40. Demiryurek Y., Nickaeen M, Zheng M, Yu M, Zahn JD, Shreiber DI, Lin H, Shan JW.  "Transport, resealing, and re-poration dynamics of two-pulse electroporation-mediated molecular delivery." Biochimica et Biophysica Acta .  2015; 1850(8): 1706-1714.

39. Lo, M.C., Wang S, Singh S, Damodaran VB, Kaplan HM, Kohn J,Shreiber DI, Zahn JD .  "Coating flexible probes with an ultra fast degrading polymer to aid in tissue insertion."  Biomedical Microdevices.   2015; 17(2): 34.

38. Ghodbane M., Kulesa A, Yu HH, Maguire TJ, Schloss RR, Ramachandran R, Zahn JD, Yarmush ML.   "Development of a low-volume, highly sensitive microimmunoassay using computational fluid dynamics-driven multiobjective optimization."  Microfluidics and Nanofluidics.   2015;18(2): 199-214.


37. Sadik M.M., Yu M,Zheng M, Zahn JD, Shan JW, Shreiber DI , Lin H.  "Scaling relationship and optimization of double-pulse electroporation."  Biophysical Journal.   2014; 106(4): 801-812.

36. Ündar A, Wang S, Palanzo D, Weaver B, Pekkan K, Agirbasli M, Zahn JD, Luciani GB, Clark JB, Wilson RP, Kunselman AR, Sano S, Belli E, Pierce WS, Myers JL.  "Outcomes of the ninth international conference on pediatric mechanical circulatory support systems and pediatric cardiopulmonary perfusion."  Artificial Organs.  2014; 38(1): 5-10.


35. Sasso, L.A., Aran K, Guan YL, Ündar A, Zahn JD.   "Continuous monitoring of inflammation biomarkers during simulated cardiopulmonary bypass using a microfluidic immunoassay device − a pilot study."  Artificial Organs.   2013; 37(1): E9-E17.

34. Zhang J, Zahn JD, Lin H.  "Transient solution for droplet deformation under electric fields. " Physical Review E Statistical, Nonlinear, and Soft Matter Physics.  2013; 87(4): 043008-0430015.

33. Zhang J, Zahn JD, Tan W, Lin H.   "A transient solution for vesicle electrodeformation and relaxation." Physics of Fluids.   2013; 25(7).


32. Sasso, LA, Johnston IH, Zheng M, Gupte RK, Ündar A, Zahn JD.  "Automated microfluidic processing platform for multiplexed magnetic bead immunoassays."  Microfluidics and Nanofluidics.  2012; 13(4): 603-612.

31. Morales, M.C., H.Lin, and J.D.Zahn, 2012.  "Continuous microfluidic DNA and protein trapping and concentration by balancing transverse electrokinetic forces."  Lab on a Chip.  2012; 12(1): 99-108.


30. Aran, K., Fok A, Sasso LA, Kamdar N, Guan Y, Sun Q, Ündar A, Zahn JD.  "Microfiltration platform for continuous blood plasma protein extraction from whole blood during cardiac surgery.  Lab on a Chip.  2011; 11(17): 2858-2868.

29. Masand, S.N., Mignone L, Zahn JD, Shreiber DI.  "Nanoporous membrane-sealed microfluidic devices for improved cell viability."  Biomedical Microdevices.  2011; 13(6): 955-961.

28. Zhang, J, Zahn JD, Lin H.  "A general analysis for the electrohydrodynamic instability of stratified immiscible fluids."  Journal of Fluid Mechanics.   2011; 681: 293-310.

27. Langhammer CG, Kutzing MK, Luo V, Zahn JD, Firestein BL.  "Skeletal myotube integration with planar microelectrode arrays in vitro for spatially selective recording and stimulation: A comparison of neuronal and myotube extracellular action potentials."  Biotechnology Press.   2011; 27(3): 891-985.


26. Aran, K, Sasso LA, Kamdar N, Zahn JD.  "Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices."  Lab on a Chip.   2010; 10.5 (2010): 548-552.

25. Morales MC,Zahn JD.  "Droplet enhanced microfluidic-based DNA purification from bacterial lysates via phenol extraction."  Microfluidics and Nanofludics .   2010; 9(6): 1041-1049.

24. Aran, K, Fok A, Guan Y, Sun Q, Zahn JD,Ündar A.  "Differential immune activation during simulated cardiopulmonary bypass procedure using freshly drawn and week-old blood − a pilot study."  Artificial Organs.  2010; 34(11): 1048-1053.

23. Sasso, LA, Ündar A, Zahn JD.  "Autonomous magnetically actuated continuous flow microimmunofluorocytometry assay."  Microfluidics and Nanofluidics.   9.6 (2010): 1041-1049.

22. Langhammer, CG, Zahn JD, Firestein BL.   "Identification and quantification of skeletal myotubule montraction and association in vitro by video microscopy."  Cytoskeleton.   2010; 67(7): 413-424.


21. Ündar A, Pauliks L, Clark JB, Zahn JD, Rosenberg G, Kunselman A, Sun Q, Pekkan K, Saliba K, Carney E, Thomas N, Freeman W, Vrana K, El-Banayosy A, Ural SH, Wilson R, Umstead TM, Floras J, Phelps DS, Weiss W, Snyder A, Yang S, Kimatian S, Cyran SE, Chinchilli VM, Guan Y, Rider A, Haines MM, Rogerson A, Alkan-Bozkaya T, Akcevin A, Sun K, Wang S, Cun L, Myers JL.   "Penn State Hershey −Center for Pediatric Cardiovascular Research."  Artifical Organs.  2009; 33(11): 883-887.

20. Miller A, Lu KC, Wang S, Umstead TM, Freeman WM, Vrana Q, Yang S, Myers JL, Phelps DS, Zahn JD, Ündar A.  "Pediatric Cardiopulmonary Bypass Circuits: A Review of the Studies Conducted at the Penn State Pediatric Cardiac Research Laboratories."  The Journal of the American Society of Extracorporeal Technology.  2009; 41(1): 50-58.

19. Harman-Boehm, I, Gal A, Raykhman AM, Zahn JD, Naidis E, Mayzel Y.  "Noninvasive Glucose Monitoring −A Novel Approach."  The Journal of Diabetes Science and Technology.  2009; 3(2): 253-260.


18. Hsieh YC, Zahn JD.   "On-chip Microdialysis System with Flow Through Glucose Sensing Capabilities." The Journal of Diabetes Science and Technology 2007; 1(3): 375-383.

17. Yang S, Ündar A,Zahn JD.  "Continuous Cytometric Bead Processing Within a Microfluidic Device for Bead Based Sensing Platforms."  Lab on a Chip.  2007; 7(5): 588-595.

16. Hsieh YC, Zahn JD.  "On-chip Microdialysis System with Flow Through Sensing Components."  Lab on a Chip.  2007; 22(11): 2422-2428.


15. Yang S, Ji B, Ündar A, Zahn JD.  "Microfluidic Devices for Continuous Blood Plasma Separation and Analysis During Pediatric Cardiopulmony Bypass Procedures."  ASIAO Journal.  2006; 52(6): 698-704.

14. Zahn JD, Reddy V.  "Two phase micromixing and analysis using electrohydrodynamic instabilities."  Microfluidics and Nanofluidics.  2006; 2(5): 399-415.

13.Yang S, Ündar A, Zahn JD.   "A microfluidic device for continuous, real time blood plasma separation."  Lab on a Chip.  20007; 6(7): 871-880.

12. Leyton-Mange J, Yang S, Hoskins MH, Kunz RF, Zahn JD, Dong C.  "Design of a Side View Particle Imaging Velocimetry for Cell-Substrate Adhesion Studies."  Lab on a Chip.  2006; 128(2): 271-278


11. Yang S,A. Ündar, and J.D. Zahn.  "Blood Plasma Separation in Microfluidic Channels Using Flow Rate Control."   ASAIO Journal.  2005; 51(15): 585-590.

10. Hsieh YC, Zahn JD.  "Glucose Recovery in a Microfluidic Microdialysis Biochip."   Sensors and Actuators B; Chemical  2005; 107: 49-656.

9. Reddy V, Zahn JD.  "Interfacial Stabilization of Organic-Aqueous Two Phase Microflows for a Miniaturized DNA Extraction Module."   Journal of Colloidal and Interfacial Science  2005; 286(1);158-165.

8. Zahn JD, Hsieh YC, Yang M.  "Components of an Integrated Microfluidic Device for Continuous Glucose Monitoring with Responsive Insulin Delivery."  Diabetes Technology and Therapeutics.  2005; 7(3): 536-545.

7. Zahn JD, Treboutich D, Liepmann D.  "Microdialysis Microneedles for Continous Medical Monitoring."  Biomedical Microdevices.  2005; 7(1): 59-69.


6. Muthukrishnan G, Roberts CA, Chen YC, Zahn JD, Hancock WO. .  "Patterning Surface-Bound Microtubules Through Reversible DNA Hybridization."  Nano Letters.  2004; 4(11): 2127-2132.

5. Yang M, Zahn JD.  "Microneedle Insertion Force Reduction Using Vibratory Actuation."  Biomedical Microdevices.  2004; 6(3): 177-182.

4.Zahn, J.D., A. Deshmukh, A.P. Pisano, and D. Liepmann.  "Continuous On Chip Micropumping for Microneedle Enhanced Drug Delivery."  Biomedical Microdevices.  2004; 6(3): 183-190.

2003 and earlier

3. Treboutich D, Zahn JD, Prabharpandian B,Liepmann D.   "Modeling of Microfabricated Microneedles for Minimally Invasive Drug Delivery, Sampling, and Analysis."  Biomedical Microdevices.  2003; 5(3): 245-251.

2. Zahn JD, Talbot NH, Liepmann D, Pisano AP.   "Microfabricated Polysilicon Microneedles for Minimally Invasive Biomedical Devices."  Biomedical Microdevices.  2003; 2(4): 295-303.

1. Akgün E, Zahn JD, Baumes S, Brown G, Liang F, Romanienko PJ, Lewis S, Jasin M.&Nbsp; "Palindrome resolution and recombination in the mammalian germ line."  Molecular and Cell Biology.  2003; 17(9): 5559-5570.






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